Injectable nanohydroxyapatite-chitosan-gelatin micro-scaffolds induce regeneration of knee subchondral bone lesions
نویسندگان
چکیده
منابع مشابه
Bone Regeneration with Cell-free Injectable Scaffolds
Hulsart Billström, G. 2017. Bone Regeneration with Cell-free Injectable Scaffolds. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1287. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9786-6. Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to i...
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In this study, a three-dimensional chitosan-gelatin/nanohydroxyapatite (ChG/nHaP) scaffold was successfully fabricated and characterized in terms of swelling, degradation, cell proliferation, cell attachment, and mineralization characterizations. The ChG/nHaP scaffold was fabricated with a mean pore size of 100-180 μm. Our results showed that the physicochemical and biological properties of the...
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Knee osteoarthritis (OA) is a prevalent condition typically measured by the level of joint space thinning. However, it has been shown that the degree of joint space narrowing correlates poorly with the incidence and magnitude of knee pain. A review of recent and past literature suggests that chronic bone marrow edema (BME) or bone marrow lesions may be linked to pain, the progression of cartila...
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Polyhydroxybutyrate-chitosan-hydroxyapatite (PHB-CHT-HAP) composite scaffolds were prepared by the precipitation of biopolymer-nanohydroxyapatite suspensions and following lyophilisation. The propylene carbonate and acetic acid were used as the polyhydroxybutyrate and chitosan solvents, respectively. The high porous microstructure was observed in composites and the macroporosity of scaffolds (p...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-17025-6